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Modular materials composed of concentric functional “shells” with independently tuneable properties are prepared from the self-assembly of DNA and linear-dendritic hybrid polymers (see scheme; PAMAM=poly(amidoamine), PEG=poly(ethylene glycol)). These ligand-targeted systems demonstrate serum stability, low toxicity, and transfection efficiencies that exceed those of the most efficient commercially available polymer poly(ethylenimine).
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Wood et al. (2005) studied this question.
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