A three-dimensional mathematical model of cellular electrical activity uncovered quantitative features of ephaptic propagation differing from 1D models and identified an alternating propagation mode.
This 3D electrodiffusion model demonstrates that detailed membrane geometry significantly impacts cardiac action potential propagation, revealing alternating ephaptic and gap-junction-mediated mechanisms.
We study cardiac action potential propagation under severe reduction in gap junction conductance. We use a mathematical model of cellular electrical activity that takes into account both three-dimensional geometry and ionic concentration effects. Certain anatomical and biophysical parameters are varied to see their impact on cardiac action potential conduction velocity. This study uncovers quantitative features of ephaptic propagation that differ from previous studies based on one-dimensional models. We also identify a mode of cardiac action potential propagation in which the ephaptic and gap-junction-mediated mechanisms alternate. Our study demonstrates the usefulness of this modeling approach for electrophysiological systems especially when detailed membrane geometry plays an important role.
Mori et al. (2008) studied Cardiac action potential propagation under severe reduction in gap junction conductance. Three-dimensional mathematical model of cellular electrical activity vs. One-dimensional models was evaluated on Cardiac action potential conduction velocity. A three-dimensional mathematical model of cellular electrical activity uncovered quantitative features of ephaptic propagation differing from 1D models and identified an alternating propagation mode.
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