Why the study?
Two hypotheses, the gap junction hypothesis and the ephapse hypothesis, have been proposed to explain propagation of the action potential in the heart.
Comparison
Gap junction hypothesis vs ephapse hypothesis
Authors
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Supports gap junction dominance in normal hearts; leaves open ephaptic contributions if conductance falls pathologically.
This historical review highlights that while cardiac conduction primarily relies on gap junctions, ephaptic conduction remains a theoretical possibility in pathological conditions.
Edward Carmeliet (2019) studied this question.
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