Key result
Proteinuria induced by pressor substances in rats correlated significantly with the increase in filtration fraction rather than blood pressure elevation, and was absent in adrenalectomized rats.
Proteinuria induced by pressor agents in rats correlates with increases in filtration fraction rather than absolute blood pressure elevation, and requires intact adrenal function or corticosterone replacement to maintain renal blood supply.
Should not yet change practice; leaves open filtration fraction and adrenal roles in proteinuria mechanisms for future models.
The degree of proteinuria induced by different pressor doses of pig renin, angiotensin II, adrenaline and noradrenaline in rats and the permissive role played by the adrenals in this respect, were investigated. No direct relationship could be established between elevation of blood pressure and proteinuria. A significant correlation was instead found between the increase in filtration fraction produced by these substances and their proteinuric effect. The absence of proteinuria in adrenalectomized rats was attributed to the severe impairment of renal blood supply caused by adrenalectomy. Corticosterone administration restored in four out of eight cases normal renal function and a normal proteinuric response to renin and angiotensin.
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Pessina et al. (1972) studied Proteinuria. Pig renin, angiotensin II, adrenaline, noradrenaline, and adrenalectomy was evaluated on Degree of proteinuria and its relationship with blood pressure and filtration fraction. Proteinuria induced by pressor substances in rats correlated significantly with the increase in filtration fraction rather than blood pressure elevation, and was absent in adrenalectomized rats.
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