Demonstrates efficient synthesis of proline derivatives in good yields, indicating potential in drug development.
An efficient pathway to a new family of proline derivatives condensed with a benzoazepine ring has been developed. The method is based on diastereoselective gold(I)-catalyzed annulation of functionalized 1,6-allenynes integrated into an α-amino acid structure with various N -hydroxyanilines to afford the corresponding tricyclic proline analogues in moderate to good yields.
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Gribanov et al. (2026) studied this question.
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