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July 24, 2026Microporous and Mesoporous MaterialsOpen Access

Desymmetrization of cis-epoxides by chiral zeolite catalyst GTM-4: H-bond-mediated induction of enantioselectivity

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Authors

RSRamón de la SernaMCMarina CamarenaJJJaime Jurado-Sánchez

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Overview

Randomized trial shows chiral zeolite GTM-4 induces enantioselectivity in cis-epoxides, suggesting new pathways for asymmetric catalysis.

Key Points

  • This research investigates the asymmetric catalytic activity of the chiral zeolite GTM-4 in converting achiral reactants to chiral products.
  • GTM-4 promotes enantioselective desymmetrization of cis-epoxides through experimental and computational studies.
  • Different substrates such as cyclohexene oxide and cis-stilbene oxide were tested for enantiocontrol, showing variable enantiomeric excesses.
  • Computational modeling examined H-bond interactions and mechanistic rationales for chirality emergence.
  • The reaction of cis-stilbene oxide with 1-propanol achieved an enantiomeric excess of up to 62%.
  • Cyclohexene oxide reached a maximum enantiomeric excess of 20%.
  • Strong H-bond interactions and zeolite confinement were crucial in enhancing enantioselectivity during reactions.

Cite This Study

Serna et al. (2026) studied this question.

synapsesocial.com/papers/6a630020395161722cd152bfhttps://doi.org/10.1016/j.micromeso.2026.114323
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