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Reveals improved detection sensitivity in peptides through dual-pH method development, suggesting a new approach for LC-MS/MS assays.
response for peptides that interacted less favorably with the bulk aqueous phase, revealing a robust "wrong-way-round" ionization regime in which reduced solution-phase control leads to greater selectivity and higher sensitivity. Incorporation of dual-pH evaluation during peptide method development therefore provides a simple strategy for maximizing sensitivity and avoiding systematic bias in targeted LC-MS/MS assays.
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Svahn et al. (2026) studied this question.
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