Background/Objectives: To assess the refractive and visual outcomes after implantation of an isofocal optic-design intraocular lens (IOL) with double C-loop haptics following cataract surgery in eyes with primary open-angle glaucoma (POAG). Methods: This was a prospective, open-label, interventional exploratory study that considered POAG eyes undergoing cataract surgery with implantation of the Isopure Serenity (Beaver-Visitec International, Inc. BVI, Waltham, MA, USA) IOL. Primary outcomes measured included manifest refraction, monocular uncorrected distance visual acuity (UDVA), corrected distance visual acuity (CDVA), uncorrected intermediate visual acuity (UIVA) and distance-corrected intermediate visual acuity (DCIVA) at 80 and 66 cm, uncorrected near visual acuity (UNVA), and distance-corrected near visual acuity (DCNVA) at 40 cm, and photopic binocular defocus curve were evaluated 3 months after surgery. Results: In total, 22 eyes of 11 patients (nine women, mean age of 68.3 ± 8.3 years) with POAG were enrolled and completed the clinical study. The study found that 100% of the eyes were within ±0.50 D and 86.36% of the eyes showed a postoperative refractive cylinder ≤ 0.25 D. The mean spherical equivalent and refractive cylinder were −0.06 ± 0.30 D and −0.13 ± 0.33 D, respectively. It was also shown that 86.36% and 100% of the eyes had 20/20 or better UDVA and CDVA, respectively. Furthermore, 95.45% and 77.27% of eyes presented a monocular DCIVA value of ≥20/32 at 80 and 66 cm, respectively, and 68.18% of eyes presented a monocular DCNVA value of ≥20/40. The mean monocular CDVA, DCIVA at 80 cm, DCIVA at 66 cm, and DCNVA were −0.09 ± 0.04, 0.12 ± 0.07, 0.21 ± 0.07 and 0.32 ± 0.07 logMAR, respectively. The binocular defocus curve showed good visual acuity at distance and intermediate vision. Conclusions: The isofocal Isopure Serenity IOL can be implanted in eyes with POAG after cataract surgery, achieving a satisfactory visual performance. Our results suggest that this IOL model is a viable option for selected patients with controlled early/moderate POAG and without central visual field involvement diagnosed with cataracts.
Takayuki Akahoshi (Wed,) studied this question.