The aim is to develop a new catalytic method for C–H sulfonamidation using Ru(II) and to understand its mechanistic pathway.
Conducted density functional theory (DFT) studies to explore the mechanistic insights.
Developed a catalytic protocol for C–H sulfonamidation of benzodiazepine scaffolds.
Validated the proposed mechanistic pathway for the Ru(II)-catalyzed reaction.
Provided insights into the efficiency of the developed sulfonamidation protocol.
Abstract
, providing further support for the proposed mechanistic pathway. Density functional theory (DFT) studies were also conducted to gain deeper mechanistic insight and to validate the developed protocol.