Background Hidradenitis suppurativa (HS) is a chronic inflammatory disorder associated with substantial morbidity, yet large real-world studies evaluating prevalence and comorbidity patterns within single healthcare systems remain limited.Methods We retrospectively reviewed adult patients diagnosed with HS across an institution-wide cohort from September 2010 through October 2025. Demographics, anxiety, depression, acne history, and median income category by zip code were analyzed.Results Among 1,882,631 patients, 15,275 had HS, corresponding to a prevalence of 0.81%. Women represented 77.8% of cases, and the highest prevalence occurred among patients aged 31 to 40 years. HS patients were more than twice as likely to have acne compared with non-HS patients (odds ratio = 2.16; 95% confidence interval, 2.09–2.23; P < 0.001). Anxiety or depression was documented in 26.9% of patients. Median household income was not significantly associated with HS.Conclusion These findings reinforce the demographic and psychosocial burden associated with HS and may assist clinicians in earlier recognition and management.
Trinh et al. (Wed,) studied this question.