What question did this study set out to answer?

This study aims to explore the effects of dietary dihydromyricetin (DHM) on antioxidant capacity, jejunal barrier function, and metabolic responses in mice.

July 24, 2026NutrientsOpen Access

Dietary Dihydromyricetin Supplementation Enhances Antioxidant Capacity and Modulates Jejunal Barrier Function, Cecal Microbiota, and Hepatic Metabolism in Mice

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Authors

WLWenjiao LiangMinistry of Agriculture and Rural Affairs LTLi TangChina West Normal University JFJinghui FanHangzhou Academy of Agricultural Sciences

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Implication

Randomized trial demonstrates improved antioxidant status and gut health in mice, suggesting metabolic benefits of dihydromyricetin supplementation.

Key Points

This study aims to explore the effects of dietary dihydromyricetin (DHM) on antioxidant capacity, jejunal barrier function, and metabolic responses in mice.
Forty-eight healthy mice were assigned to control or DHM diets (50, 100, or 200 mg/kg) for 4 weeks.
Parameters including serum biochemistry, antioxidant status, hepatic gene expression, and microbiota profiles were assessed.
Growth performance, jejunal morphology, and homocysteine metabolism-related markers were analyzed.
DHM improved serum and hepatic antioxidant status, increasing T-AOC and GSH-Px activity (p < 0.05) and decreasing MDA concentrations (p < 0.05).
DHM reduced TNF-α levels and increased IL-10 levels (p < 0.01).
DHM increased villus height and protein expression of Occludin and ZO-1 in the jejunum (p < 0.05).

Cite This Study

Liang et al. (2026) studied this question.

synapsesocial.com/papers/6a630179395161722cd160ce https://doi.org/10.3390/nu18142390

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Implication

Randomized trial demonstrates improved antioxidant status and gut health in mice, suggesting metabolic benefits of dihydromyricetin supplementation.

Dietary Dihydromyricetin Supplementation Enhances Antioxidant Capacity and Modulates Jejunal Barrier Function, Cecal Microbiota, and Hepatic Metabolism in Mice

Discussion

Member takes

Implication

Key Points

Cite This Study

Dietary Dihydromyricetin Supplementation Enhances Antioxidant Capacity and Modulates Jejunal Barrier Function, Cecal Microbiota, and Hepatic Metabolism in Mice

Discussion

Member takes

Implication

Key Points

Cite This Study

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