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July 24, 2026Tropical Medicine and HealthOpen Access

Best practices in sample management & pre-analytical quality control: overcoming challenges in resource-limited laboratory settings

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Authors

BMBlessing Kenechi Myke-MbataUniversity of AgricultureBBBruno BasilEnugu State University of Science and TechnologyNIN. IzuchukwuNile University of Nigeria

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Implication

Narrative review synthesizes strategies to improve diagnostic reliability in low-resource settings, suggesting integrative solutions.

Key Points

  • This research aims to identify strategies for enhancing pre-analytical quality control in resource-limited laboratory settings.
  • Conducted a narrative review using PRISMA guidance to select relevant literature from 2010 to 2025.
  • Critically appraised 71 studies focusing on pre-analytical quality in low- and middle-income countries.
  • Synthesized evidence within a conceptual framework addressing adaptive protocols and appropriate technologies.
  • Identified main causes of pre-analytical failures including haemolysis, misidentification, and degradation.
  • Context-adapted interventions improved specimen integrity and reduced rejection rates significantly.
  • Recommended integration of training, standardized practices, and digital systems to enhance laboratory efficiency.

Cite This Study

Myke-Mbata et al. (2026) studied this question.

synapsesocial.com/papers/6a6301a6395161722cd1632ehttps://doi.org/10.1186/s41182-026-01038-x
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