A Building Block Strategy for Construction of C(sp ³ )–SCF ₃ Bonds via Nickel-Catalyzed 1,2-Difunctionalization of Trifluoromethylthiolated Alkenes

The trifluoromethylthiol (SCF 3 ) group has emerged as a valuable motif in medicinal chemistry owing to its strong electron-withdrawing nature and its high lipophilicity. Despite significant advances in SCF 3 incorporation into a variety of molecules, the construction of C(sp 3 )–SCF 3 bonds remains a notable challenge. Herein, we present a Ni-catalyzed 1,2-difunctionalization using a newly designed SCF 3 -containing synthon readily accessible in a single step.