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July 24, 2026Scientific ReportsOpen Access

Mental health literacy mediates associations of self rated health and chronic disease status with anxiety and depression in Chinese residents

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Authors

DKDeliang KongJZJiyuan ZhongYLY Li

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Overview

Randomized trial reveals mental health literacy mediates outcomes of health and chronic disease in residents, suggesting integrated interventions are needed.

Key Points

  • This research aims to explore the mediating effects of mental health literacy on the relationship between self-rated health, chronic disease, and psychological outcomes like anxiety and depression.
  • Conducted a large-scale stratified multistage population survey with 36,874 residents in Chongqing, China.
  • Assessed mental health literacy using the National Mental Health Literacy Questionnaire (NMHLQ) and screened for anxiety and depression with PHQ-9 and GAD-7.
  • Utilized multivariable regression analysis and Bootstrap resampling to test mediating effects and model robustness.
  • Odds of anxiety were 2.76 (95% CI 2.40–3.17) for those with fair/poor self-rated health; depression 3.31 (95% CI 2.97–3.69); and comorbidity 2.98 (95% CI 2.55–3.49).
  • Mental health literacy was negatively associated with anxiety, depression, and comorbidity outcomes.
  • MHL had an independent protective role and provided a 7-8% partial mediation in the relationship between self-rated health and chronic disease on mental health outcomes.

Cite This Study

Kong et al. (2026) studied this question.

synapsesocial.com/papers/6a630201395161722cd166fahttps://doi.org/10.1038/s41598-026-63540-w
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