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July 24, 2026Journal of Computer Assisted Tomography

Complementary Role of Whole-Body MRI and CT in Hematologic Malignancies and Bone Marrow Disorders

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Authors

EGElena GhotbiMFMatthew FrickJCJoselle Cook

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Overview

Clinical review compares whole-body MRI and CT for diagnosing and managing hematologic malignancies, indicating practical considerations for each modality.

Key Points

  • This review aims to evaluate the comparative effectiveness of whole-body MRI and CT in diagnosing and managing hematologic malignancies and bone marrow disorders.
  • Provided a scenario-based comparison of WBCT and WBMRI across various clinical applications.
  • Synthesize data from 3 studies involving 152 patients to assess CT-MRI concordance in multiple myeloma.
  • Discussed emerging CT techniques and their implications for marrow imaging.
  • The pooled CT-MRI concordance in multiple myeloma was 0.895 (95% CI: 0.834-0.935), indicating substantial agreement.
  • The broader pooled concordance across other disease categories was 0.797 (95% CI: 0.667-0.885), reflecting variability in clinical scenarios.
  • WBMRI is preferable for non-neoplastic marrow disorders, while FDG-PET/CT is standard for adult lymphoma.

Cite This Study

Ghotbi et al. (2026) studied this question.

synapsesocial.com/papers/6a630224395161722cd16978https://doi.org/10.1097/rct.0000000000001918
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