Key result
Single-step long balloon inflation resulted in a similar rate of final TIMI 3 flow (90.0% vs 88.5%) but a significantly greater delta TIMI flow grade compared to conventional inflation.
Why the study?
Slow flow during PCI for AMI culprit lesions carries adverse outcomes, and whether single-step long balloon inflation during stent deployment improves TIMI flow grades compared with conventional inflation was unknown.
Does single-step long balloon inflation (≥60 seconds) during stent deployment improve final TIMI flow grade compared to conventional inflation in patients undergoing IVUS-guided PCI for acute myocardial infarction?
Cohort (n=336)
No
Does single-step long balloon inflation (≥60 seconds) during stent deployment improve final TIMI flow grade compared to conventional inflation in patients undergoing IVUS-guided PCI for acute myocardial infarction?
Single-step long balloon inflation (≥60s) during stent deployment safely improves the delta TIMI flow grade (coronary reperfusion from baseline) in patients undergoing primary PCI for acute myocardial infarction with low attenuation plaque.
Answers are grounded in this paper and cite their sources.
May warrant consideration in IVUS-guided AMI PCI; extends RCT evidence on stent deployment optimization.
Background: There is a substantial risk of slow flow during percutaneous coronary intervention (PCI) for the culprit lesion in acute myocardial infarction (AMI), which can lead to adverse outcomes. We hypothesized that single-step long balloon inflation during stent deployment was associated with a more favorable final Thrombolysis in Myocardial Infarction (TIMI) flow grade. This retrospective study aimed to compare both the final TIMI flow grade and the delta TIMI flow grade in intravascular ultrasound (IVUS)-guided PCI for AMI between patients with long balloon inflation and those with conventional inflation. Methods and Results: Long inflation was defined as single-step inflation ≥60 s at stent deployment. The primary endpoints were achievement of the final TIMI flow grade 3 and the delta TIMI flow grade, defined as the difference between the initial and final grades. We analyzed 336 AMI patients with attenuation plaque on IVUS, dividing them into a long inflation group (n=50) and a conventional inflation group (n=286). Despite a significantly higher TIMI thrombus grade in the long inflation group (P<0.001), the rate of the final TIMI 3 flow was similar (90% vs. 88.5%; P=1.00). However, the delta TIMI flow grade was significantly greater in the long inflation group (P=0.028). Conclusions: Single-step long balloon inflation may be a simple and feasible method to achieve optimal final TIMI flow in IVUS-guided PCI for AMI.
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Watanabe et al. (2025) conducted a cohort in Acute myocardial infarction with low attenuation plaque (n=336). Single-step long balloon inflation (≥60 s) vs. Conventional balloon inflation (<60 s or multi-step) was evaluated on Achievement of final TIMI flow grade 3 (p=1.00). Single-step long balloon inflation resulted in a similar rate of final TIMI 3 flow (90.0% vs 88.5%) but a significantly greater delta TIMI flow grade compared to conventional inflation.
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