Key result
Peripheral endothelial dysfunction was identified in 51.3% of NSTEMI patients and was associated with a significantly higher rate of coronary angioplasty (P=0.037).
Why the study?
To evaluate peripheral endothelial function using the EndoPAT 2000 device in patients with NSTEMI and correlate it with clinical characteristics.
Does peripheral endothelial dysfunction correlate with coronary lesion severity and clinical characteristics in patients with NSTEMI?
Observational (n=39)
Yes
Does peripheral endothelial dysfunction correlate with coronary lesion severity and clinical characteristics in patients with NSTEMI?
Peripheral endothelial dysfunction is highly prevalent (51.3%) in NSTEMI patients at 72 hours post-admission and correlates with a higher need for coronary angioplasty.
Purpose: Evaluation of peripheral endothelial function using EndoPAT 2000 device in patients with non-ST-elevation myocardial infarction (NSTEMI) and correlation with clinical characteristics of the patients. Material and methods: The study included 39 patients with NSTEMI, hospitalized in 2 PCI centers, in the period 03.2022-03.2023. At 72 hours after admission, peripheral endothelial function was assessed using the EndoPAT 2000 device. Patients were divided into 2 groups according to the presence of peripheral endothelial dysfunction (RHI <1.67). Statistical analysis of the data was performed using the t-test and the χ2 test. Results: The average value of the reactive hyperemia index (RHI) was 1.73 ± 0.47. Endothelial dysfunction was diagnosed in 51,3% of NSTEMI patients. Group I included 19 patients with normal endothelial function (RHI>1.67), and group II – 20 patients with endothelial dysfunction (RHI<1.67). In the group of patients with endothelial dysfunction, two- or three-vessel disease prevailed (χ2=2.7, p=0.43) and a higher rate of coronary angioplasty was recorded (χ2=4.36, p=0.037). Conclusion: Peripheral endothelial dysfunction estimated by the EndoPat 2000 method is identified in 51,3% of patients with NSTEMI. The endothelial dysfunction correlated with severity of coronary lesions. Further studies are needed to assess the diagnostic and prognostic value of the method.
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Dicusar et al. (2023) conducted an observational in Non-ST-elevation myocardial infarction (NSTEMI) (n=39). Peripheral endothelial dysfunction (RHI <1.67) vs. Normal endothelial function (RHI >1.67) was evaluated on Coronary angioplasty (p=0.037). Peripheral endothelial dysfunction was identified in 51.3% of NSTEMI patients and was associated with a significantly higher rate of coronary angioplasty (P=0.037).
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