Key result
In patients with peripheral arterial disease, those with a reactive hyperemia index <1.67 had significantly higher median thrombomodulin levels (20.3 U/mL) compared to those with an index ≥1.67 (13.7 U/mL).
Why the study?
Does serum thrombomodulin level correlate with reactive hyperemia index and ankle brachial pressure index in patients with peripheral arterial disease?
Population
17 patients with peripheral arterial disease defined as >50% vessel stenosis, median age 71, 82% male…
Design
Cross-sectional
Authors
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TM elevation associates with impaired RHI in PAD; hypothesis-generating for dual endothelial markers, needs prospective validation before clinical use.
Cross-Sectional (n=17)
No
Does serum thrombomodulin level correlate with reactive hyperemia index and ankle brachial pressure index in patients with peripheral arterial disease?
Absolute Event Rate: 20.3% vs 13.7%
p-value: p=0.023
In patients with peripheral arterial disease, serum thrombomodulin levels correlate with the reactive hyperemia index, suggesting both may serve as useful markers for evaluating endothelial dysfunction.
Igari et al. (2016) conducted a cross-sectional in Peripheral Arterial Disease (n=17). Reactive hyperemia index (RHI) < 1.67 vs. Reactive hyperemia index (RHI) ≥ 1.67 was evaluated on Serum thrombomodulin (TM) level (U/mL) (p=0.023). In patients with peripheral arterial disease, those with a reactive hyperemia index <1.67 had significantly higher median thrombomodulin levels (20.3 U/mL) compared to those with an index ≥1.67 (13.7 U/mL).
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