Key result
Peripheral arterial tonometry (lnPAT) was unrelated to flow-mediated dilation (r = -0.0471, p = 0.414) but correlated with VTI and was decreased in patients with coronary artery disease (p < 0.0001).
Why the study?
Does peripheral arterial tonometry correlate with traditional measures of endothelial function (FMD and VTI) in patients with and without CAD?
Population
304 patients (mean age 48.9 ± 12.5 years), including 105 with coronary artery disease (CAD) and 199 controls.
Comparison
Peripheral arterial tonometry (PAT) vs Flow-mediated dilation and hyperemic peak…
Design
Cross-sectional
Authors
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May refine microvascular phenotyping in CAD; leaves open its incremental prognostic value over FMD.
Cross-Sectional (n=304)
Does peripheral arterial tonometry correlate with traditional measures of endothelial function (FMD and VTI) in patients with and without CAD?
Effect estimate: r = -0.0471
p-value: p=0.414
Peripheral arterial tonometry (lnPAT) correlates with hyperemic peak velocity time integral (VTI) but not flow-mediated dilation (FMD), and is significantly reduced in patients with coronary artery disease, suggesting it measures microvascular rather than macrovascular endothelial function.
Martin et al. (2012) conducted a cross-sectional in Coronary artery disease (n=304). Peripheral arterial tonometry (PAT) vs. Flow-mediated dilation (FMD) and hyperemic peak velocity time integral (VTI) was evaluated on Correlation between lnPAT and FMD (r = -0.0471, p=0.414). Peripheral arterial tonometry (lnPAT) was unrelated to flow-mediated dilation (r = -0.0471, p = 0.414) but correlated with VTI and was decreased in patients with coronary artery disease (p < 0.0001).
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