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May 30, 2017Vascular MedicineOpen Access

LnRHI derived by PAT showed good reliability in diabetic nephropathy (ICC = 0.863), satisfactory reliability in HFpEF (ICC = 0.557) and HFrEF (ICC = 0.576), but poor reliability in arterial hypertension (ICC = 0.125).

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Why the study?

Is peripheral arterial tonometry (PAT) a reliable method to assess endothelial dysfunction in patients with heart failure, diabetic nephropathy, and arterial hypertension?

Population

91 patients divided into four groups: heart failure with preserved ejection fraction, heart failure with…

Design

Cohort

Follow-up

median 7 days (range 4-14 days)

Authors

FWFabian WeisrockMFMax FritschkaSBSebastian Beckmann

Discussion

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Overview

LnRHI shows moderate-to-good reliability in select CV cohorts; leaves open routine PAT adoption pending prospective validation.

Key Points

  • To evaluate the test-retest reliability of pulse amplitude tonometry using the natural logarithmic transformed reactive hyperaemia index across diverse cardiovascular disease populations.
  • Assessed 91 patients (mean age: 65±9.7 years, 32% female) across four cohorts: heart failure with preserved ejection fraction (n=25), heart failure with reduced ejection fraction (n=22), diabetic nephropathy (n=21), and arterial hypertension (n=23) (NCT02299960).
  • Performed two separate pulse amplitude tonometry measurements per participant at a median interval of 7 days (range: 4–14 days).
  • Natural logarithmic transformed reactive hyperaemia index showed good reliability in diabetic nephropathy (intra-class correlation [ICC] = 0.863) and satisfactory reliability in heart failure with preserved ejection fraction (ICC = 0.557) and reduced ejection fraction (ICC = 0.576).
  • Test-retest reliability was poor in participants with arterial hypertension (ICC = 0.125), potentially due to variations in heart rate and time of assessment.

Structured PICO

Is peripheral arterial tonometry (PAT) a reliable method to assess endothelial dysfunction in patients with heart failure, diabetic nephropathy, and arterial hypertension?

P
Population
91 patients (mean age: 65±9.7 years, 32% female) divided into four groups: heart failure with preserved ejection fraction (HFpEF) (n=25), heart failure with reduced ejection fraction (HFrEF) (n=22), diabetic nephropathy (n=21), and arterial hypertension (n=23).
I
Intervention
Two separate peripheral arterial tonometry (PAT) measurements at a median interval of 7 days (range 4-14 days).
O
Outcome
Test-retest reliability of PAT using the natural logarithmic transformed reactive hyperaemia index (LnRHI).surrogate

Peripheral arterial tonometry is a reliable non-invasive technique to assess endothelial dysfunction in patients with heart failure and diabetic nephropathy, but lacks sufficient test-retest reliability in patients with arterial hypertension.

Limitations

  • Variations in heart rate and the respective time of the assessments may have affected reliability in the arterial hypertension group.

Cite This Study

Weisrock et al. (2017) studied this question.

synapsesocial.com/papers/6a700cc6fe4101aa97dffd5bhttps://doi.org/10.1177/1358863x17706752
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Also Consider

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