Key result
A post-exercise reduction of brachial flow-mediated dilatation > 1.3% predicted major cardiovascular events (20 events total) over 85 months in patients with intermittent claudication.
Why the study?
The predictive value of effort-induced endothelial dysfunction for cardiovascular events in patients with intermittent claudication had not been studied previously.
Does exercise-induced endothelial dysfunction predict major cardiovascular events in patients with intermittent claudication?
Cohort (n=44)
Does exercise-induced endothelial dysfunction predict major cardiovascular events in patients with intermittent claudication?
A post-exercise reduction of brachial FMD > 1.3% is a significant predictor of major cardiovascular events in patients with intermittent claudication.
Answers are grounded in this paper and cite their sources.
Effort-induced endothelial dysfunction may predict events in IC; leaves open its clinical utility pending prospective validation.
Endothelial dysfunction, evaluated by flow-mediated dilatation (FMD), predicts adverse cardiovascular events in patients with intermittent claudication (IC). IC is an example of repeated ischemia/reperfusion injury that may contribute to the progression of vascular disease by worsening endothelial function, a trigger for acute cardiovascular events. The predictive value of effort-induced endothelial dysfunction for cardiovascular events in patients with IC has not been studied previously. The objective of this study was to assess whether exercise-induced endothelial dysfunction is predictive of adverse cardiovascular outcome in IC. In 44 patients with IC, we measured brachial artery FMD by B-mode ultrasonography at rest and 10 minutes after a maximal treadmill exercise. Treadmill exercise halved the FMD (from 3.5 ± 0.6% to 1.45 ± 0.46%, p < 0.05). After a follow-up period of 85 (72–98) months, a total of 20 major cardiovascular events occurred. In a multivariate analysis, a post-exercise reduction of brachial FMD > 1.3% was predictive for cardiovascular events. Maximal exercise-induced endothelial dysfunction is predictive of cardiovascular events in patients with IC.
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Migliacci et al. (2021) conducted a cohort in Intermittent claudication (n=44). Exercise-induced endothelial dysfunction (post-exercise reduction of brachial FMD > 1.3%) was evaluated on Major cardiovascular events. A post-exercise reduction of brachial flow-mediated dilatation > 1.3% predicted major cardiovascular events (20 events total) over 85 months in patients with intermittent claudication.
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