Key result
The Tei index showed strong discriminatory ability for Takotsubo syndrome compared to acute coronary syndrome and controls (AUC 0.836, p<0.0001), with an optimal diagnostic cut-off of ≥0.418.
Why the study?
Evidence for the Tei index in the context of Takotsubo syndrome is currently limited.
Does the Tei index improve the diagnostic discrimination of Takotsubo syndrome compared to acute coronary syndrome and controls?
Observational (n=138)
Does the Tei index improve the diagnostic discrimination of Takotsubo syndrome compared to acute coronary syndrome and controls?
The Tei index is a simple, fast, and inexpensive echocardiographic parameter that provides strong discriminatory ability to help distinguish Takotsubo syndrome from acute coronary syndrome.
Answers are grounded in this paper and cite their sources.
TI may aid TTS differentiation from ACS retrospectively; leaves open prospective validation before routine diagnostic use.
BACKGROUND: Tei index (TI) is a combined myocardial performance index for overall cardiac function, the sensitivity of which seems to be better than that of systolic and diastolic parameters alone. Evidence for TI in the context of Takotsubo syndrome (TTS) is currently limited, which is why we chose to investigate this parameter in affected patients. SUBJECTS AND METHODS: Patients with TTS (n = 51), acute coronary syndrome (ACS; n = 29), and controls (n = 58) were retrospectively investigated. Laboratory and echocardiographic parameters including TI were analyzed for their ability to discriminate TTS in the total study cohort. RESULTS: TI was the highest, and thus most pathological, in patients with TTS (median 0.516 vs. ACS: 0.355 vs. control: 0.313, p < 0.0001) and showed the best discriminatory ability for TTS (AUC: 0.836, p < 0.0001). A cut-off for diagnosis of TTS was calculated at ≥0.418 (specificity: 83.5% and sensitivity: 74.0%) by means of the Youden index. CONCLUSION: The discriminatory ability of TI was better than that of other echocardiographic parameters such as LV systolic function. Due to the simple, fast, and inexpensive way of calculating TI, diagnostic workup with conventional parameters could be complemented by TI in patients with suspected TTS.
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Mirna et al. (2022) conducted an observational in Suspected Takotsubo Syndrome (n=138). Tei index vs. Acute coronary syndrome and controls was evaluated on Discriminatory ability for Takotsubo syndrome (AUC 0.836, p=<0.0001). The Tei index showed strong discriminatory ability for Takotsubo syndrome compared to acute coronary syndrome and controls (AUC 0.836, p<0.0001), with an optimal diagnostic cut-off of ≥0.418.
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