Key result
The Tei index demonstrated better discriminatory ability for myocarditis than ejection fraction (AUC 0.71 vs 0.57, p<0.0001) and E/e' (AUC 0.64).
Why the study?
Evidence for the Tei index in myocarditis is limited, though it may add value to conventional diagnostic workup.
Does the Tei index improve the discriminatory ability for acute myocarditis compared to conventional echocardiographic parameters?
Observational (n=119)
Does the Tei index improve the discriminatory ability for acute myocarditis compared to conventional echocardiographic parameters?
The Tei index provides better discriminatory ability for acute myocarditis than conventional echocardiographic parameters like EF and E/e', making it a useful adjunctive diagnostic tool.
Answers are grounded in this paper and cite their sources.
May support adjunctive TI use in myocarditis workup; leaves open need for prospective validation before practice change.
Background: Tei index (TI) is a combined myocardial performance index, which was found to be more sensitive for overall cardiac dysfunction than systolic or diastolic parameters alone. Currently, there is only limited evidence for this measure in the context of myocarditis. Thus, TI could add additional benefits to conventional diagnostic workup. Methods: TI of patients with myocarditis (n = 40), acute coronary syndrome (n = 29) and controls (n = 50) was retrospectively analyzed concerning its discriminatory ability for myocarditis. Results: TI was most pathological in patients with myocarditis (median 0.41 vs. 0.35 vs. 0.31, p < 0.0001). Its discriminatory ability was better than that of EF or E/e’ (AUCs: TI: 0.71, p < 0.0001; EF: 0.57, p = 0.112; E/e’: 0.64, p = 0.983), which was also verified in logistic regression analysis (B(SE) = 0.81(0.23), p = 0.0004). The association of TI with myocarditis remained significant even after correction for confounders in propensity score weighted analysis. Conclusions: The TI showed a better discriminatory ability for myocarditis than conventional echocardiographic parameters. Since TI is easily conducted, it might be a helpful adjunctive tool to supplement conventional diagnostic modalities in patients with suspected myocarditis.
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Mirna et al. (2022) conducted an observational in Acute Myocarditis (n=119). Tei index vs. Ejection fraction and E/e' was evaluated on Discriminatory ability for myocarditis (AUC) (AUC 0.71, p=<0.0001). The Tei index demonstrated better discriminatory ability for myocarditis than ejection fraction (AUC 0.71 vs 0.57, p<0.0001) and E/e' (AUC 0.64).
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