Key result
Single cardiac Na channels in mouse ventricular myocytes at 35 degrees C open frequently with multiple levels and mean open times of approximately 40 to 74 microseconds.
Using an improved patch clamp technique, single cardiac Na channels in mouse ventricular myocytes were shown to open frequently with multiple levels and open times in the tens of microseconds at near-physiological temperatures.
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Improved patch-clamp enables low-noise single Na channel recording at 35°C in myocytes; extends techniques for cardiac ion channel research.
Klaus Benndorf (1994) studied this question. Patch clamp technique at 35 degrees C was evaluated on Single-channel Na currents properties (amplitude, open probability, mean open time). Single cardiac Na channels in mouse ventricular myocytes at 35 degrees C open frequently with multiple levels and mean open times of approximately 40 to 74 microseconds.
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