Key result
This review discusses the pathogenesis of chronic thromboembolic pulmonary hypertension and highlights pulmonary endarterectomy, balloon pulmonary angioplasty, and drug therapy as effective treatments.
Why the study?
Chronic thromboembolic pulmonary hypertension has a complex pathogenesis and poor prognosis if untreated, with evolving treatment options including pulmonary endarterectomy, balloon pulmonary angioplasty, and drug therapy.
This review summarizes the pathophysiology and evolving treatment landscape for CTEPH, emphasizing the roles of PEA, BPA, and emerging medical therapies.
Informs evolving CTEPH care pathways; leaves open optimal sequencing and patient selection for multimodal therapies.
Chronic thromboembolic pulmonary hypertension (CTEPH) is a condition in which an organic thrombus remains in the pulmonary artery (PA) even after receiving anticoagulation therapy for more than 3 months and is complicated by pulmonary hypertension (PH), leading to right-sided heart failure and death. CTEPH is a progressive pulmonary vascular disease with a poor prognosis if left untreated. The standard treatment for CTEPH is pulmonary endarterectomy (PEA), which is usually performed only in specialized centers. In recent years, balloon pulmonary angioplasty (BPA) and drug therapy for CTEPH have also shown good results. This review discusses the complex pathogenesis of CTEPH and presents the standard of care, PEA, as well as a new device called BPA, which is showing remarkable progress in efficacy and safety. Additionally, several drugs are now demonstrating established evidence of efficacy in treating CTEPH.
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Otani et al. (2023) conducted a review in Chronic thromboembolic pulmonary hypertension (CTEPH). Pulmonary endarterectomy (PEA), balloon pulmonary angioplasty (BPA), and drug therapy was evaluated. This review discusses the pathogenesis of chronic thromboembolic pulmonary hypertension and highlights pulmonary endarterectomy, balloon pulmonary angioplasty, and drug therapy as effective treatments.
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