Key result
Preterm birth in rats did not affect MMP2 expression in the left ventricle, but decreased MMP9 content by day 7 and increased it by day 21 compared with term rats.
Why the study?
To evaluate the influence of preterm birth on the expression of matrix metalloproteinases MMP2 and MMP9 in the left ventricular wall during early postnatal ontogenesis.
Does preterm birth alter the expression of MMP2 and MMP9 in the left ventricle of rats during the early postnatal period?
Does preterm birth alter the expression of MMP2 and MMP9 in the left ventricle of rats during the early postnatal period?
Preterm birth alters the temporal expression pattern of MMP9, but not MMP2, in the left ventricle of rats during the early postnatal period.
May indicate altered LV remodeling after preterm birth; leaves open relevance to human neonates and need for translational studies.
The influence of preterm birth on the expression of matrix metalloproteinases (MMP2 and MMP9) in the wall of the left ventricle of the rat heart in the early postnatal period of ontogenesis (up to 21 days) was studied. The hearts of preterm (gestation duration 21 and 21.5 days) and term (gestation duration 22 days) Wistar rats on days 7 and 21 of the postnatal period of ontogenesis were studied immunohistochemically in the experiment. Preterm birth has no effect on the pattern of immunohistochemical staining of MMP2 in the wall of the left ventricle of rats, while the content of MMP9 decreases by day 7 and increases by day 21 of the postnatal period of ontogenesis, compared with that of term rats.
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Иванова et al. (2022) studied Preterm birth. Preterm birth vs. Term birth (gestation duration 22 days) was evaluated on Expression of matrix metalloproteinases (MMP2 and MMP9) in the wall of the left ventricle. Preterm birth in rats did not affect MMP2 expression in the left ventricle, but decreased MMP9 content by day 7 and increased it by day 21 compared with term rats.
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