Key result
Preterm birth in Wistar rats increased the specific volume of myocardial stroma in the early postnatal period, with more pronounced changes at shorter gestation periods.
Why the study?
Preterm birth correlates with adult cardiovascular disease, making the identification of early postnatal cardiac morphofunctional changes a priority to prevent long-term negative effects.
Preterm birth in a rat model leads to early postnatal structural changes in the left ventricular myocardium, specifically increased stromal volume, which may contribute to long-term cardiovascular risk.
Answers are grounded in this paper and cite their sources.
Hypothesis-generating for early left ventricular structural remodeling following preterm birth; leaves open whether targeted.
Preterm birth is positively correlated with a predisposition to the development of diseases of the cardiovascular system in adulthood. The identification of morphofunctional changes in the heart of prematurely born children in the early postnatal period is a high-priority task, as it will prevent or correct the development of long-term negative effects of prematurity on their cardiovascular system. Histological and morphometric analysis of the myocardium of the heart left ventricle of Wistar rats born on days 21 and 21.5 of pregnancy (the full gestation period is 22 days) was carried out. It has been shown that preterm birth increases the specific volume of rat myocardial stroma in the early postnatal period of ontogenesis. Preterm birth does not change the number and coefficient of mast-cell degranulation in the myocardium of the left ventricle in the rat heart. Morphological changes in the myocardium of preterm rats are more pronounced with a shorter gestation period (21 days of pregnancy).
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Иванова et al. (2022) studied Preterm birth. Preterm birth vs. Full gestation period (22 days) was evaluated on Morphological changes in the myocardium of the left ventricle (specific volume of myocardial stroma, mast-cell degranulation). Preterm birth in Wistar rats increased the specific volume of myocardial stroma in the early postnatal period, with more pronounced changes at shorter gestation periods.
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