Key result
Reduction in morning systolic blood pressure was an independent determinant of urinary albumin excretion reduction (P=0.001) in patients with morning hypertension, irrespective of treatment regimen.
Why the study?
Does reduction in morning systolic blood pressure improve urinary albumin excretion in patients with morning hypertension?
RCT (n=95)
Open-label with blinded endpoint assessment
Randomized
Yes
Does reduction in morning systolic blood pressure improve urinary albumin excretion in patients with morning hypertension?
Absolute Event Rate: -18% vs -8%
p-value: p=<0.001
Reduction in morning systolic blood pressure is a key independent determinant of reduced urinary albumin excretion in patients with morning hypertension, regardless of the specific antihypertensive regimen used.
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May aid UAE monitoring in morning hypertension; leaves open prospective validation of modifiable factors.
Kai et al. (2013) conducted an RCT in Morning hypertension (n=95). Losartan/hydrochlorothiazide (HCTZ) combination vs. High-dose losartan (100 mg) was evaluated on Morning systolic blood pressure (SBP) reduction (p=<0.001). Reduction in morning systolic blood pressure was an independent determinant of urinary albumin excretion reduction (P=0.001) in patients with morning hypertension, irrespective of treatment regimen.
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