Higher quartiles of lipid accumulation product and cardiometabolic index were strongly associated with nonalcoholic fatty liver disease, with the highest LAP quartile in women showing a 13.18-fold increased risk compared to the lowest quartile.
Cross-Sectional (n=14,407)
No
Do lipid accumulation product (LAP) and cardiometabolic index (CMI) accurately identify nonalcoholic fatty liver disease (NAFLD) in Chinese adults?
LAP and CMI are accurate, sex-specific indexes for screening NAFLD in Chinese adults, with greater diagnostic accuracy in women.
Odds Ratio: 13.183 (95% CI 8.512–20.417)
p-value: p=<0.001
BACKGROUND: Lipid accumulation product (LAP) and cardiometabolic index (CMI) are two novel obesity-related indexes associated with enhancing metabolic disease (MD) risk. Current evidences suggest that the differences in sex hormones and regional fat distribution in both sexes are directly correlated with MD and nonalcoholic fatty liver disease (NAFLD) risk. Hence, NAFLD incidences reflect sex differences. Herein, we examined the accuracy of LAP and CMI in diagnosing NAFLD in both sexes. METHODS: Overall, 14,407 subjects, who underwent health check-up in the northeastern China, were enrolled in this study, and their corresponding LAP and CMI were calculated. Abdominal ultrasonography was employed for NAFLD diagnosis. Multivariate analyses were analyzed potential correlations between LAP and/or CMI and NAFLD. Odds ratios (ORs) and 95% confidence intervals (CIs) were evaluated. Receiver operating characteristic curve analyses was executed for the exploration of the diagnostic accuracies. Areas under the curves (AUCs) with 95%CIs were calculated. RESULTS: NAFLD prevalence increased with elevated quartiles of LAP and CMI in both sexes. In multivariate logistic regression analyses, LAP and CM expressed as continuous variables or quartiles, significantly correlated with NAFLD. The ORs for the top versus bottom quartile of LAP and CMI for NAFLD were 13.183 (95%CI = 8.512-20.417) and 8.662 (95%CI = 6.371-11.778) in women and 7.544 (95%CI = 5.748-9.902) and 5.400 (95%CI = 4.297-6.786) in men. LAP and CMI exhibited larger AUCs, compared to other obesity-related indexes in terms of discriminating NAFLD. The AUCs of LAP and CMI were 0.860 (95%CI = 0.852-0.867) and 0.833 (95%CI = 0.825-0.842) in women and 0.816 (95%CI = 0.806-0.825) and 0.779 (95%CI = 0.769-0.789) in men. CONCLUSIONS: LAP and CMI are convenient indexes for the screening and quantification of NAFLD within a Chinese adult population. Their associations with NAFLD are substantially greater in women than men.
Liu et al. (Thu,) conducted a cross-sectional in Nonalcoholic fatty liver disease (NAFLD) (n=14,407). Lipid accumulation product (LAP) and cardiometabolic index (CMI) vs. Lowest quartile of LAP and CMI was evaluated on Presence of NAFLD (top vs bottom quartile of LAP in women) (OR 13.183, 95% CI 8.512-20.417, p=<0.001). Higher quartiles of lipid accumulation product and cardiometabolic index were strongly associated with nonalcoholic fatty liver disease, with the highest LAP quartile in women showing a 13.18-fold increased risk compared to the lowest quartile.