Key result
Dietary rose hip supplementation in ApoE-null mice markedly reduced blood pressure, atherosclerotic plaques, oxidized LDL, and total cholesterol compared to a high-fat diet alone.
Why the study?
Does dietary rose hip supplementation prevent atherosclerotic plaque formation in ApoE-null mice on a high-fat diet?
Does dietary rose hip supplementation prevent atherosclerotic plaque formation in ApoE-null mice on a high-fat diet?
Dietary rose hip supplementation prevents atherosclerotic plaque formation and improves vascular function in a mouse model of atherosclerosis.
Answers are grounded in this paper and cite their sources.
Supports anti-atherosclerotic effects of rose hip in this animal RCT; extends prior rodent data but leaves open human translation.
Atherosclerosis is a disease in which atheromatous plaques develop inside arteries, leading to reduced or obstructed blood flow that in turn may cause stroke and heart attack. Rose hip is the fruit of plants of the genus Rosa, belonging to the Rosaceae family, and it is rich in antioxidants with high amounts of ascorbic acid and phenolic compounds. Several studies have shown that fruits, seeds and roots of these plants exert antidiabetic, antiobesity and cholesterol-lowering effects in rodents as well as humans. The aim of this study was to elucidate the mechanisms by which rose hip lowers plasma cholesterol and to evaluate its effects on atherosclerotic plaque formation. ApoE-null mice were fed either an HFD (CTR) or HFD with rose hip supplementation (RH) for 24 weeks. At the end of the study, we found that blood pressure and atherosclerotic plaques, together with oxidized LDL, total cholesterol and fibrinogen levels were markedly reduced in the RH group. Fecal cholesterol content, liver expression of Ldlr and selected reverse cholesterol transport (RCT) genes such as Abca1, Abcg1 and Scarb1 were significantly increased upon RH feeding. In the aorta, the scavenger receptor Cd36 and the proinflammatory Il1β genes were markedly down-regulated compared to the CTR mice. Finally, we found that RH increased nitric oxide-mediated dilation of the caudal artery. Taken together, these results suggest that rose hip is a suitable dietary supplement for preventing atherosclerotic plaques formation by modulating systemic blood pressure and the expression of RCT and inflammatory genes.
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Cavalera et al. (2017) studied Atherosclerosis. Rose hip supplementation vs. High-fat diet (HFD) was evaluated on Plasma cholesterol and atherosclerotic plaque formation. Dietary rose hip supplementation in ApoE-null mice markedly reduced blood pressure, atherosclerotic plaques, oxidized LDL, and total cholesterol compared to a high-fat diet alone.
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