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This research investigates the effects of flavonoids from Rosa sterilis S. D. Shi on lipid metabolism and obesity in mice.

May 25, 2026npj Science of FoodOpen Access

Flavonoids of Rosa sterilis S. D. Shi alleviate high-fat diet-induced hyperlipidemia in mice by activation of autophagy

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Randomized trial shows flavonoids reduce hyperlipidemia in mice, suggesting a new treatment strategy.

This research investigates the effects of flavonoids from Rosa sterilis S. D. Shi on lipid metabolism and obesity in mice.
Mice were induced with obesity symptoms through a high-fat diet.
Flavonoids from Rosa sterilis were administered to assess their impact on lipid metabolism.
Autophagy activation and gene expression related to fat synthesis and degradation were evaluated.
FRS treatment reduced liver injury and fat accumulation in high-fat diet-induced mice.
FRS significantly increased autophagy, leading to reduced lipid accumulation and downregulation of adipogenic genes.
Blocking autophagy with BAFA1 negated the beneficial effects of FRS on lipid metabolism.

Wang et al. (2026) studied this question.

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