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October 23, 2025Food & FunctionOpen Access

Flavonoids from Rosa roxburghii Tratt Fermentation Broth Inhibit Adipogenesis via the SIRT1 Pathway: Insights from Metabolomics and Network Pharmacology

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Authors

MLMi LiuYRYiqiu RuanCHChangyüdong Huang

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Overview

Metabolomics reveals flavonoids inhibit adipogenesis in adipocytes, suggesting mechanisms through SIRT1 pathways.

Key Points

  • Inhibition of adipogenesis was observed with flavonoids from Rosa roxburghii, impacting fat cell formation.
  • In metabolic analysis, key alterations in flavor-related compounds were noted post-fermentation.
  • Using network pharmacology, the relationship between flavonoids and SIRT1 was explored thoroughly.
  • These findings highlight that Rosa roxburghii may provide natural dietary options for obesity control.

Cite This Study

Liu et al. (2025) studied this question.

synapsesocial.com/papers/68f9a0eb8ea8f2f37ee94cbahttps://doi.org/10.1039/d5fo02814k
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Flavonoids in <i>Rosa roxburghii</i> Tratt Fermentation Broth Ameliorate Obesity via <scp>DNMT3a</scp>/<scp>SIRT1</scp>‐Mediated Epigenetic Modulation2025
  2. 2Elucidating the potential anti-liver cancer mechanisms of the medicinal food Rosa roxburghii Tratt. by integrating HPLC-Q Exactive MS/MS, network pharmacology, and in vitro validation2026
  3. 3Flavonoids of Rosa sterilis S. D. Shi alleviate high-fat diet-induced hyperlipidemia in mice by activation of autophagy2026
  4. 4Regulation mechanism of Rosa roxburghii Tratt. (Cili) fruit vinegar on non-alcoholic fatty liver disease2025 · 1 citations
  5. 5Fermentation with Lactobacillus reuteri and Lachancea fermentati improves the bioactivity and flavor-sensory characteristics of Rosa roxburghii Tratt. juice2026