What type of study is this?

This is a Observational study (also classified as: Molecular docking, Reduced representation bisulfite sequencing analysis, Surface plasmon resonance).

September 10, 2025Food Science & NutritionOpen Access

Flavonoids in Rosa roxburghii Tratt Fermentation Broth Ameliorate Obesity via DNMT3a/SIRT1‐Mediated Epigenetic Modulation

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RRTFB reduced obesity markers in HFD-fed rats, indicating its potential therapeutic effects.
The intervention significantly lowered MDA, IL-6, TNF-α, and DNMT3a, while enhancing antioxidant activities.
RRBS analysis revealed numerous differential methylation regions in genes related to fat metabolism in HFD-fed rats.
Flavonoids in RRTFB were confirmed as active components, binding to DNMT3a and altering its activity.

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Implication

This study demonstrates RRTFB's effects on obesity in HFD-fed rats, suggesting DNMT3a and SIRT1 as key mediators.

Cite This Study

Liu et al. (2025) studied this question.

synapsesocial.com/papers/68c187269b7b07f3a06114c4 https://doi.org/10.1002/fsn3.70892

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Flavonoids in Rosa roxburghii Tratt Fermentation Broth Ameliorate Obesity via DNMT3a/SIRT1‐Mediated Epigenetic Modulation

Key Points

Discussion

Implication

Cite This Study

Flavonoids in Rosa roxburghii Tratt Fermentation Broth Ameliorate Obesity via DNMT3a/SIRT1‐Mediated Epigenetic Modulation

Key Points

Discussion

Implication

Cite This Study

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