What does this research mean for the field?

Rosa laxa Retz. fruit extract safely alleviates hyperlipidemia and hepatic steatosis by modulating the 'Lipid and Atherosclerosis' pathway through key targets including NFE2L2, CYP1A1, NOS3, and MAPK1. Novelty: ClaimNovelty.NOVEL_FINDING. Consensus alignment: ConsensusAlignment.NEUTRAL.

What question did this study set out to answer?

This research aims to characterize the chemical profile of Rosa laxa Retz. fruits and identify their effects on hyperlipidemia.

June 6, 2026MetabolitesOpen Access

Integrated Chemical Profiling, Serum Pharmacochemistry, and Network Pharmacology to Elucidate the Anti-Hyperlipidemic Effects of Rosa laxa Retz. Fruits from Different Geographical Origins

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Authors

YHYuan HeXinjiang Medical University QFQianqian FengXinjiang Medical University WZWenhui ZhaoXinjiang Medical University

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Implication

Randomized trial evaluates anti-hyperlipidemic effects in HLP mice, indicating safety and efficacy of Rosa laxa fruits.

Key Points

This research aims to characterize the chemical profile of Rosa laxa Retz. fruits and identify their effects on hyperlipidemia.
UPLC-QTOF-MS for chemical profiling from different geographical origins.
Establishment of an HLP mouse model to evaluate pharmacodynamic effects.
Integration of network pharmacology and molecular docking to elucidate mechanisms.
FRLE significantly improved TC, LDL-C, and corrected HDL-C levels in HLP mice (extraction yield 24.19%).
Safety evaluations showed no significant toxicity at 16.6 g/kg maximum dose.
Fruits modulated key targets in the 'Lipid and Atherosclerosis' pathway, including NFE2L2 and MAPK1.

Cite This Study

He et al. (2026) studied this question.

synapsesocial.com/papers/6a23b9ca71a5da9775e758e3 https://doi.org/10.3390/metabo16060392

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Integrated Chemical Profiling, Serum Pharmacochemistry, and Network Pharmacology to Elucidate the Anti-Hyperlipidemic Effects of Rosa laxa Retz. Fruits from Different Geographical Origins

Discussion

Member takes

Implication

Key Points

Cite This Study

Integrated Chemical Profiling, Serum Pharmacochemistry, and Network Pharmacology to Elucidate the Anti-Hyperlipidemic Effects of Rosa laxa Retz. Fruits from Different Geographical Origins

Discussion

Member takes

Implication

Key Points

Cite This Study

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