August 1, 2025

Inhibition of Lipid Accumulation in NAFLD Liver by Extract of Rosa laevigata Fruit Extract through Activation of the PI3K-AKT Signaling Pathway

View Full Paper

Ask AI

Bookmark

Authors

Discussion

Inhibition of lipid accumulation improves key indicators in naflD cells, suggesting potential therapeutic use of rosal laevigata extract.

The extract of rosal laevigata significantly reduced triglycerides by 55.9% and total cholesterol by 37.1% in NAFLD models.
Key liver enzymes, aspartate transaminase and alanine transaminase, decreased by 67.5% and 51.1% respectively after treatment with the extract.
Antioxidant levels were enhanced, with total antioxidant capacity increasing by 182.5%, highlighting the extract's protective effect.
The therapeutic effects are likely mediated through the activation of the pi3k-akt signaling pathway and its role in lipid metabolism.

Ni et al. (2025) studied this question.

View Full Paper

Ask AI

Bookmark