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INTRODUCTION: Transdermal drug delivery (TDD) is becoming more recognized as a noninvasive method particularly suitable for vulnerable populations. TDD offers an alternative to oral drug delivery, bypassing issues related to poor absorption and metabolism. However, the application of TDD is limited to a few drugs due to the skin's barrier. Various techniques, including passive methods like nanoparticles (NPs), are being explored to enhance drug permeability through the skin. AREAS COVERED: This review shows the benefit of incorporating inorganic NPs with TDD in improving drug delivery through the skin. Despite the potential of these techniques, there are currently only a few research studies that utilize them. This review addresses the scarcity of research incorporating inorganic NPs with TDD. It also aims to summarize both inorganic NPs and TDD in the pharmaceutical industry, highlighting the advantages of incorporating these novel drug delivery systems with each other. EXPERT OPINION: Given the potential benefits of incorporating inorganic NPs into TDD systems, there is a need for increased research and attention in this area. The review encourages scientists to address the existing research gap and explore the advantages of combining these innovative drug delivery systems to advance the field.
Nimrawi et al. (Sat,) studied this question.