Nanodiagnosis: A matrix-metalloproteinase (MMP) sensitive gold-nanoparticle (AuNP) imaging probe quenches conjugated near-infrared (NIR) dyes with high efficiency and is specifically activated by the target MMPs (see picture, left). With this system, nanomolar amounts of protease can be detected—both in vitro and in vivo. Experiments disclose an apparent positive contrast in MMPs-positive tumor-bearing mice (right).
No takes yet. Share an insight, caveat, or question.
Lee et al. (2008) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: