Periportal Space Lesions: Imaging Spectrum and Differential Diagnosis

The periportal region is a complex anatomical area that includes important structures such as the hepatic artery, bile ducts, lymphatics, and nerves. Due to its rich architecture, diagnosing lesions in this space presents a significant challenge for radiologists. Various pathological conditions can affect this region, ranging from vascular and lymphatic diseases to infectious and malignant lesions. This article explores the main periportal conditions through various imaging methods, including ultrasound, computed tomography (CT), magnetic resonance imaging (MRI), and magnetic resonance cholangiopancreatography (MRCP). Therefore, understanding specific radiological manifestations is essential for differentiating clinical conditions and guiding appropriate treatment.