Intraductal Papillary Neoplasm of the Bile Duct: Simplifying Findings

Intraductal papillary neoplasm of the bile duct (IPNB) is a rare tumor, considered a pre-invasive lesion derived from the biliary epithelium. Although it shares similarities with intraductal papillary mucinous neoplasm (IPMN) of the pancreas, only one-third of patients present with mucin hypersecretion. The World Health Organization (WHO) formalized the description of IPNB in 2010 as a "non-invasive biliary papillary or villous neoplasm covering delicate fibrovascular stalks in dilated bile ducts." Despite advancements, literature still lacks multicenter studies on its progression and prognosis. This article reviews the clinical, epidemiological, and radiological features of IPNB, highlighting its recent classifications and key findings, contributing to appropriate management based on a literature review and case examples.