Answers are grounded in this paper and cite their sources.
Novel inhibitors targeting cathepsin K were developed from a high-throughput screening hit, implying potential therapeutic applications.
Starting from the high-throughput screening hit 1a, novel cathepsin K inhibitors have been developed based on a purine scaffold. High-resolution X-ray structures of several derivatives have revealed the binding mode of these unique cysteine protease inhibitors.
No takes yet. Share an insight, caveat, or question.
Altmann et al. (2004) studied this question.
Synapse has enriched 10 related papers. Consider them for comparative context: