Answers are grounded in this paper and cite their sources.
The use of different receptor blocking agents and single-unit recording techniques indicates that feedback inhibition of brain noradrenaline neurons by tricyclic antidepressants is mediated by presynaptic alpha-receptors. After chronic imipramine treatment, noradrenaline neurons in the locus coeruleus of rat brain remained partly depressed, in agreement with clinical data. They were, however, resistant to further inhibition by imipramine or clonidine.
No takes yet. Share an insight, caveat, or question.
Svensson et al. (1978) studied this question.
Synapse has enriched 10 related papers. Consider them for comparative context: