Key result
Alternating MOPP and ABVD courses without radiotherapy in children with Hodgkin's disease resulted in a 90% disease-free survival rate with minimal toxicity.
Why the study?
Does alternating MOPP and ABVD chemotherapy without radiotherapy provide adequate disease-free survival and reduced toxicity in children with Hodgkin's disease?
Population
21 children with Hodgkin's disease, ages 5-18 years (median 14 years), 7 females and 14 males.
Design
Case_series
Authors
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Should not yet change practice in pediatric Hodgkin lymphoma; leaves open need for randomized trials of alternating MOPP/ABVD without radiotherapy.
Observational (n=21)
Does alternating MOPP and ABVD chemotherapy without radiotherapy provide adequate disease-free survival and reduced toxicity in children with Hodgkin's disease?
Alternating MOPP and ABVD for 6 cycles without radiotherapy may be an adequate and less toxic treatment for children with Hodgkin's disease.
Berg et al. (1997) conducted an observational in Hodgkin's disease (n=21). Alternating MOPP and ABVD courses without radiotherapy was evaluated on Disease-free survival. Alternating MOPP and ABVD courses without radiotherapy in children with Hodgkin's disease resulted in a 90% disease-free survival rate with minimal toxicity.
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