The ultrasonographic stiffness index (US-SI) detected 'true' pulmonary artery stiffening in patients with left heart disease with 83.3% sensitivity and 95.8% specificity.
Observational (n=24)
Does the ultrasonographic stiffness index (US-SI) accurately identify pulmonary artery stiffening in patients with left heart disease?
The ultrasonographic stiffness index (US-SI) provides a robust and accurate non-invasive method for detecting pulmonary artery stiffening in patients with left heart disease.
Effect estimate: 83.3% sensitivity and 95.8% specificity
AIMS: Pulmonary hypertension (PH) is a common complication of left heart disease (LHD) that leads to right heart failure and death. Pulmonary artery (PA) stiffening has recently emerged as an important diagnostic and prognostic parameter in PH. The present study aimed to develop and validate an ultrasonographic index to identify PA stiffening in PH due to LHD. METHODS AND RESULTS: First, ultrasonographic stiffness index (US-SI) was derived from pulmonary arterial (PA) radial strain (PA-RS), diameter, and stroke volume in rat model and correlated with ex vivo measured 'true' PA stiffness E. Then, US-SI was validated in a cohort of 24 LHD patients with or without PH prior to heart transplantation and again compared with 'true' PA stiffness measured ex vivo in collected PA specimens. In rats, ultrasonographic PA-RS and US-SI correlated closely with E, and both were able to detect 'true' PA stiffening with ≥80% sensitivity and specificity. In LHD patients, even though ultrasonographic right PA radial strain or US-SI correlated similarly with E, observer assessment and testing for diagnostic validity identified US-SI as more robust and accurate method that detects 'true' PA stiffening with 83.3% sensitivity and 95.8% specificity. CONCLUSIONS: Both PA strain and US-SI allow for ultrasonographic detection of PA stiffening in patients or animal models with LHD; however, US-SI identifies patients with stiffened PA with higher diagnostic validity and accuracy.
Kucherenko et al. (Thu,) conducted a observational in Left heart disease with or without pulmonary hypertension (n=24). Ultrasonographic stiffness index (US-SI) vs. Ex vivo measured 'true' pulmonary artery stiffness was evaluated on Detection of 'true' pulmonary artery stiffening (83.3% sensitivity and 95.8% specificity). The ultrasonographic stiffness index (US-SI) detected 'true' pulmonary artery stiffening in patients with left heart disease with 83.3% sensitivity and 95.8% specificity.