Key result
Targeted deficiency of u-PA or plasminogen prevented the 2.5-fold hypoxia-induced rise in right ventricular pressure and pulmonary vascular remodeling observed in wild-type mice.
Why the study?
Does deficiency of u-PA or plasminogen prevent hypoxia-induced pulmonary hypertension and vascular remodeling in mice?
Does deficiency of u-PA or plasminogen prevent hypoxia-induced pulmonary hypertension and vascular remodeling in mice?
Deficiency of u-PA or plasminogen protects against hypoxia-induced pulmonary hypertension and vascular remodeling in mice, indicating a key role for u-PA-mediated plasmin generation in hypoxic pulmonary vascular disease.
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No immediate clinical implications from murine data; leaves open u-PA/plasmin as target in human pulmonary hypertension.
Levi et al. (2001) studied Hypoxia-induced pulmonary hypertension. Targeted deficiency of u-PA or plasminogen vs. Wild-type mice was evaluated on Right ventricular pressure. Targeted deficiency of u-PA or plasminogen prevented the 2.5-fold hypoxia-induced rise in right ventricular pressure and pulmonary vascular remodeling observed in wild-type mice.