What question did this study set out to answer?

The aim is to investigate the hemodynamic changes associated with metoprolol administration in patients undergoing an acute myocardial infarction.

January 12, 1978Acta Medica Scandinavica

Hemodynamic Effects of the Cardioselective β‐Blocking Agent Metoprolol in Acute Myocardial Infarction

Q: What is the clinical evidence from this study?

Population: Acute Myocardial Infarction (n=10). Intervention: Metoprolol. Primary outcome: Hemodynamic changes (heart rate, blood pressure, cardiac output, stroke volume, pulmonary artery end diastolic pressure, preejection period).

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Key result

Metoprolol administration in acute myocardial infarction decreased heart rate, systolic BP, and cardiac output without causing hemodynamic deterioration during the first 24 hours.

Why the study?

Does metoprolol alter hemodynamic parameters safely in patients with uncomplicated acute myocardial infarction?

Key Points

The aim is to investigate the hemodynamic changes associated with metoprolol administration in patients undergoing an acute myocardial infarction.
Ten patients with uncomplicated transmural myocardial infarction received an intravenous dose of metoprolol (15 mg) within the first 24 hours.
Follow-up treatment included oral metoprolol (25-50 mg) administered at 6-hour intervals for 24 hours.
Hemodynamic parameters such as heart rate, blood pressure, and cardiac output were monitored throughout the study.
Heart rate, systolic blood pressure, and cardiac output decreased significantly post-injection.
Stroke volume and diastolic blood pressure remained unchanged for the group.
The preejection period was prolonged in all patients post-administration of metoprolol.

Structured PICO

Does metoprolol alter hemodynamic parameters safely in patients with uncomplicated acute myocardial infarction?

Population

10 patients with uncomplicated transmural myocardial infarction, without contraindications like heart failure or hypotension, monitored for 24 hours on metoprolol.

Intervention

Metoprolol 15 mg i.v. injected within the first 24 hours after onset of chest pain, followed by oral therapy (25-50 mg at 6-hour intervals) for 24 hours.

Outcome

Hemodynamic changes (heart rate, systolic BP, cardiac output, stroke volume, diastolic BP, pulmonary artery end diastolic pressure, preejection period) over 24 hours.surrogate

Intravenous followed by oral metoprolol can be safely administered in the acute phase of uncomplicated myocardial infarction without causing hemodynamic deterioration.

Discussion

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Implication

Early metoprolol reduces heart rate, systolic pressure, and output in acute MI; extends hemodynamic data while leaving outcome effects open.

Cite This Study

Málek et al. (1978) studied Acute Myocardial Infarction (n=10). Metoprolol was evaluated on Hemodynamic changes (heart rate, blood pressure, cardiac output, stroke volume, pulmonary artery end diastolic pressure, preejection period). Metoprolol administration in acute myocardial infarction decreased heart rate, systolic BP, and cardiac output without causing hemodynamic deterioration during the first 24 hours.

synapsesocial.com/papers/6a632feebc34223c9a288202 https://doi.org/10.1111/j.0954-6820.1978.tb08424.x

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Implication

Early metoprolol reduces heart rate, systolic pressure, and output in acute MI; extends hemodynamic data while leaving outcome effects open.

Hemodynamic Effects of the Cardioselective β‐Blocking Agent Metoprolol in Acute Myocardial Infarction

Key Points

Structured PICO

Discussion

Implication

Cite This Study

Hemodynamic Effects of the Cardioselective β‐Blocking Agent Metoprolol in Acute Myocardial Infarction

Key Points

Structured PICO

Discussion

Implication

Cite This Study

Also Consider

Also Consider