Key result
The Clinical Frailty Scale independently predicted 30-day mortality in octogenarians admitted to German ICUs, with the odds of death increasing by 44% for each point increase on the scale (OR 1.44).
Why the study?
Does the Clinical Frailty Scale predict 30-day mortality in octogenarians admitted to German ICUs?
Cohort (n=308)
Yes
Does the Clinical Frailty Scale predict 30-day mortality in octogenarians admitted to German ICUs?
Odds Ratio: 1.44 (95% CI 1.052–1.964)
p-value: p=0.023
The Clinical Frailty Scale is an easily determinable and valuable tool for predicting 30-day ICU survival in octogenarians, facilitating intensive care decision-making.
CFS may refine prognosis in octogenarian ICU patients; leaves open effects on decisions or outcomes in prospective studies.
BACKGROUND: In intensive care units (ICU) octogenarians become a routine patients group with aggravated therapeutic and diagnostic decision-making. Due to increased mortality and a reduced quality of life in this high-risk population, medical decision-making a fortiori requires an optimum of risk stratification. Recently, the VIP-1 trial prospectively observed that the clinical frailty scale (CFS) performed well in ICU patients in overall-survival and short-term outcome prediction. However, it is known that healthcare systems differ in the 21 countries contributing to the VIP-1 trial. Hence, our main focus was to investigate whether the CFS is usable for risk stratification in octogenarians admitted to diversified and high tech German ICUs. METHODS: This multicentre prospective cohort study analyses very old patients admitted to 20 German ICUs as a sub-analysis of the VIP-1 trial. Three hundred and eight patients of 80 years of age or older admitted consecutively to participating ICUs. CFS, cause of admission, APACHE II, SAPS II and SOFA scores, use of ICU resources and ICU- and 30-day mortality were recorded. Multivariate logistic regression analysis was used to identify factors associated with 30-day mortality. RESULTS: Patients had a median age of 84 [IQR 82-87] years and a mean CFS of 4.75 (± 1.6 standard-deviation) points. More than half of the patients (53.6%) were classified as frail (CFS ≥ 5). ICU-mortality was 17.3% and 30-day mortality was 31.2%. The cause of admission (planned vs. unplanned), (OR 5.74) and the CFS (OR 1.44 per point increase) were independent predictors of 30-day survival. CONCLUSIONS: The CFS is an easy determinable valuable tool for prediction of 30-day ICU survival in octogenarians, thus, it may facilitate decision-making for intensive care givers in Germany. TRIAL REGISTRATION: The VIP-1 study was retrospectively registered on ClinicalTrials.gov (ID: NCT03134807 ) on May 1, 2017.
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Muessig et al. (2018) conducted a cohort in Intensive care unit admission in octogenarians (n=308). Clinical Frailty Scale (CFS) vs. Lower CFS score was evaluated on 30-day mortality (OR 1.44, 95% CI 1.052-1.964, p=0.023). The Clinical Frailty Scale independently predicted 30-day mortality in octogenarians admitted to German ICUs, with the odds of death increasing by 44% for each point increase on the scale (OR 1.44).
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