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Upconversion emissions from rare-earth nanoparticles have attracted much interest as potential biolabels, for which small particle size and high emission intensity are both desired. Herein we report a facile way to achieve NaYF(4):Yb,Er@CaF(2) nanoparticles (NPs) with a small size (10-13 nm) and highly enhanced (ca. 300 times) upconversion emission compared with the pristine NPs. The CaF(2) shell protects the rare-earth ions from leaking, when the nanoparticles are exposed to buffer solution, and ensures biological safety for the potential bioprobe applications. With the upconversion emission from NaYF(4):Yb,Er@CaF(2) NPs, HeLa cells were imaged with low background interference.
Wang et al. (Wed,) studied this question.