Combined burn and smoke inhalation injury impairs ovine hypoxic pulmonary vasoconstriction*

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Key Points

To investigate the effects of combined burn and smoke inhalation injuries on pulmonary vascular responses and respiratory function.
Prospective, placebo-controlled, randomized, single-blinded trial
Used chronically instrumented ewes, randomized to injury (n=6) or control (n=6) groups
Assessed hypoxic pulmonary vasoconstriction via pulmonary arterial blood flow measurements at baseline and 24 and 48 hours post-injury.
Injury group showed a significant increase in NOx plasma levels (injury: 16 +/- 1.6 µmol/L; p<.01) compared to sham.
3-nitrotyrosine content increased markedly post-injury (216 +/- 8 nM vs. sham 30 +/- 3 nM; p<.001).
Significant loss of hypoxic pulmonary vasoconstriction noted (-90.5% from baseline at 48 hrs; p<.001).

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Examines hypoxic pulmonary vasoconstriction impairment in sheep post injury, suggesting significant respiratory challenges.

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Westphal et al. (2006) studied this question.

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