What is the clinical evidence from this study?

Study design: Observational. Population: Type 2 diabetes mellitus (n=182). Intervention: Type 2 diabetes mellitus vs. Non-diabetic controls. Primary outcome: Standard deviation of normal-to-normal RR intervals (SDNN) (MD -17.2, 95% CI -27.4 to -7.0, p=0.001).

What does this research mean for the field?

Elderly patients with type 2 diabetes mellitus exhibit significantly reduced heart rate variability that inversely correlates with systemic inflammatory markers, indicating autonomic dysfunction. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

What question did this study set out to answer?

The study aimed to evaluate heart rate variability (HRV) changes in elderly patients with type 2 diabetes mellitus and their relationship with laboratory findings.

May 30, 2025Marmara medical journalOpen Access

Assessment of heart rate variability in elderly patients with type 2 diabetes mellitus

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Key result

Type 2 diabetes mellitus in elderly patients was independently associated with a significant reduction in heart rate variability, including a 17.2 ms decrease in SDNN compared to controls.

Why the study?

Cardiac autonomic neuropathy is a prevalent complication of type 2 DM associated with elevated cardiovascular risk, prompting evaluation of HRV changes and their relationship with laboratory findings in elderly patients.

Does Type 2 Diabetes Mellitus reduce heart rate variability in elderly patients?

Key Points

The study aimed to evaluate heart rate variability (HRV) changes in elderly patients with type 2 diabetes mellitus and their relationship with laboratory findings.
Retrospective analysis of 182 subjects aged ≥65 years divided into a diabetes group (n=72) and control group (n=110).
24-hour Holter ECG monitoring was conducted to analyze time and frequency domain HRV parameters.
Correlations between HRV and laboratory markers, including inflammatory markers, were evaluated.
Heart rate variability parameters (SDNN: p=0.004, SDANN: p=0.008, SDNN index: p=0.015) were significantly lower in the diabetes group.
Frequency domain parameters (POWER: p=0.004, VLF: p=0.006, LF: p=0.007, HF: p=0.049) were also significantly reduced.
A negative correlation was observed between HRV and WBC count (p <0.001), indicating systemic inflammation.

Study Design

Type

Observational (n=182)

Multicenter

Structured PICO

Does Type 2 Diabetes Mellitus reduce heart rate variability in elderly patients?

Population

182 elderly patients aged 65 years and older, including 72 with type 2 diabetes mellitus and 110 controls, who underwent 24-hour Holter ECG monitoring.

Exposure

Type 2 Diabetes Mellitus (exposure)

Comparator

Non-diabetic control group

Outcome

Changes in heart rate variability (HRV) parameters in both time and frequency domains (SDNN, SDANN, SDNN index, RMSSD, pNN50, POWER, VLF, LF, HF, LF/HF ratio) measured via 24-hour Holter ECG monitoringsurrogate

Main Result

Mean Difference: -17.2 (95% CI -27.4–-7)

Absolute Event Rate: 104.31% vs 118.74%

p-value: p=0.001

Limitations

Retrospective design precludes assessing the relationship between HRV changes and long-term clinical outcomes.
Lack of data regarding the duration of diabetes.
Influence of daily activities, stress, and environmental factors during 24-hour Holter recordings could not be entirely controlled.
Specific impacts of medications such as beta-blockers and ACE inhibitors on HRV were not analyzed in detail.
Reduction of LDL cholesterol levels by statins could have complicated the evaluation of the relationship between LDL cholesterol and HRV.
Cannot assess the relationship between changes in HRV and long-term clinical outcomes
Data regarding the duration of diabetes was not available
Influence of daily activities, stress, and environmental factors during 24-hour Holter recordings could not be entirely controlled
Specific impacts of medications such as beta-blockers and ACE inhibitors on HRV were not analyzed in detail
Reduction of LDL cholesterol levels by statins could have complicated the evaluation of the relationship between LDL cholesterol and HRV

Discussion

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Implication

HRV-lab associations in elderly T2DM are hypothesis-generating; leaves open prospective validation before any clinical application.

Cite This Study

Demirci et al. (2025) conducted an observational in Type 2 diabetes mellitus (n=182). Type 2 diabetes mellitus vs. Non-diabetic controls was evaluated on Standard deviation of normal-to-normal RR intervals (SDNN) (MD -17.2, 95% CI -27.4 to -7.0, p=0.001). Type 2 diabetes mellitus in elderly patients was independently associated with a significant reduction in heart rate variability, including a 17.2 ms decrease in SDNN compared to controls.

synapsesocial.com/papers/6a633ee96a6e856b79094ea1 https://doi.org/10.5472/marumj.1708027

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Assessment of heart rate variability in elderly patients with type 2 diabetes mellitus

Key Points

Study Design

Structured PICO

Main Result

Limitations

Discussion

Implication

Cite This Study

Assessment of heart rate variability in elderly patients with type 2 diabetes mellitus

Key Points

Study Design

Structured PICO

Main Result

Limitations

Discussion

Implication

Cite This Study

Also Consider

Also Consider