CardiacNOsignalling in the metabolic syndrome
Key result
Metabolic syndrome increases oxidative and nitrative stress, impairing cardiac NO signalling and promoting dysfunction, which may be mitigated by therapies like ACE inhibitors and sGC activators.
Design
Review
Authors
Discussion
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Implication
Provides a mechanistic rationale for targeting the nitric oxide pathway in metabolic syndrome; leaves open whether.
PICO
P
Population
Metabolic syndrome
E
Exposure / Comparator
NO signalling modulation
Understanding the dysregulation of cardiac NO signalling in metabolic syndrome may guide the development of targeted therapies to prevent cardiac dysfunction.
Cite This Study
Pecháňová et al. (2014) conducted a review in Metabolic syndrome. NO signalling modulation was evaluated. Metabolic syndrome increases oxidative and nitrative stress, impairing cardiac NO signalling and promoting dysfunction, which may be mitigated by therapies like ACE inhibitors and sGC activators.